Intended Use: This antibody is designed for the
specific localization of CDX2 in formalin-fixed, paraffinembedded (FFPE) tissue sections. Evaluation must be performed
by a qualified pathologist.
Summary and Explanation: CDX2, a member of the caudal-related homeobox family, is an
intestine-specific transcription factor that regulates both
proliferation and differentiation in intestinal epithelial cells. It
plays an important role in triggering cells towards the
phenotype of differentiated villus enterocytes as well as in the
maintenance of the phenotype. Clone CDX2-88 reacts with a
conserved epitope of the 40kD CDX2 protein localized in the
nucleus. It exclusively marks nuclei of colonic epithelial cells
and colorectal cancers on formalin-fixed, paraffin-embedded
Storage and Handling: Store at 2-8°C. Fresh dilutions, if required, should be prepared
prior to use and are stable and steady for up to one day at room
temperature (20-26°C). Diluted antibody preparations can be
refrigerated or frozen for extended shelf life.